Chubby Bee

Skin barrier in atopic dermatitis: beyond filaggrin

Atopic dermatitis is a chronic inflammatory skin disease with complex pathogenesis, where changes in the skin barrier and imbalance of the immune system are relevant factors.

The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation, and physical trauma.

The main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ), and components of the innate immune system.

Enhancement of keratinocyte differentiation by rose absolute oil.